张在军，神经药理学博士，副研究员，硕士生导师。主要从事神经药理学教学、科研工作，研究方向为治疗神经退行性疾病(帕金森病、脑中风、阿尔茨海默病等)的多功能神经保护活性化合物的研究与开发。主持包括国家自然科学基金，广东省自然科学基金和广州市科技计划等各类项目10余项。已发表论文100余篇，被SCI收录论文70余篇，其中在Free Radical Biology and Medicine, British Journal of Pharmacy, Journal of Neurochemisty, CNS Neuroscience & Therapy等国际SCI期刊发表第一或通讯作者论文30余篇，最高单篇论文他引达100多次。参与申请发明专利20余项，获授权10余项。
主要研究方向：
神经药理学
主要学术奖励:
中国博士后基金-香港学者学会香江学者奖（2013年）
主持的科研项目：
1. 2015广东省自然科学基金自由申请项目(2015A030313317)
2. 2013国家自然科学基金青年基金项目(81303251)
3. 2013年度广州市科技计划科学研究专项 (2014J4100097)
4. 2013广东省医学科研基金(A2013353)
5. 2012澳门大学横向合作研究项目(40113010)
近两年发表的代表性论文(第一或通讯作者,限10篇)：
1.Tetramethylpyrazine nitrone activates AKT/CREB through increasing BDNF expression to promote post-ischemic neuroregeneration and recovery of neurological functions in rats.Br J Pharmacol.2017 Nov 21. doi: 10.1111/bph.14102. [Epub ahead of print]
2.Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B.Neuropharmacology. 2017 Nov;126:12-24. doi: 10.1016/j.neuropharm.2017.08.014.
3.A novel Danshensu/tetramethylpyrazine derivative induces vasorelaxation on rat aorta and exerts cardioprotection in dogs.Eur J Pharmacol.2017 Oct 21;818:158-166. doi: 10.1016/j.ejphar.2017.10.034. [Epub ahead of print]
4.Neuroprotective and axonal outgrowth-promoting effects of tetramethylpyrazine nitrone in chronic cerebral hypoperfusion rats and primary hippocampal neurons exposed to hypoxia.Neuropharmacology. 2017 May 15;118:137-147.
5.Tetramethylpyrazine nitrone protects retinal ganglion cells against N-methyl-D-aspartate-induced excitotoxicity.Journal of Neurochemistry. 2017 May;141(3):373-386.
6.Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy.Sci Rep.2016 Nov 14;6:37148. doi: 10.1038/srep37148.
7.Tetramethylpyrazine nitrone improves neurobehavioral functions and confers neuroprotection on rats with traumatic brain injury.Neurochemical Research2016 Nov;41(11):2948-2957.
8.Discovery, Synthesis, and Functional Characterization of a Novel Neuroprotective Natural Product from the Fruit of Alpinia oxyphylla for use in Parkinson’s Disease Through LC/MS–Based Multivariate Data Analysis–Guided Fractionation.Journal of Proteome Research2016, 5;15(8):2595-606.
9.Multifunction of Chrysin in Parkinson’s Model: Anti-Neuronal Apoptosis, Neuroprotection via Activation of MEF2D, and Inhibition of Monoamine Oxidase-B.Journal of Agricultural and Food Chemistry2016, 6;64(26):5324-33.
10.No synergism between bis(propyl)-cognitin and rasagiline on protecting dopaminergic neurons in Parkinson’s disease mice.Neural Regen Res2016, 11(8):1339-1346.
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