唐金山
唐金山，男，博士，研究员，硕士生导师。2008年7月毕业于沈阳药科大学，获药学（天然药物化学）专业博士学位。同年进入暨南大学生物医学工程博士后流动站从事科研工作，2010年12月就职于暨南大学药学院/中药及天然药物研究所。2014年3月至2015年3月前往美国Cleveland State University访问交流，2016、2017年前往美国Case Western Reserve University医学院药理系进行短期交流。目前已在国际和国内重要杂志发表文章47篇，其中SCI收录文章38篇；申请和主持国家自然科学基金3项，企业委托横向课题1项；申请并获得授权专利4项。
主要研究方向：
1.从中药及天然药物（包括微生物）中寻找抗癌活性物质
2.活性天然产物的结构修饰及其作用机制研究
近五年承担的主要科研项目：
1.强心苷诱导核孤儿受体Nur77表达及其抗癌作用机制、构效关系，国家自然科学基金面上项目（NSFC 81673320），58万，2017, 1-2020, 12.
2.强心苷联合化疗药“以毒攻毒”抗癌新机制研究，国家自然科学基金海外及港澳学者合作研究基金（NSFC 81728022），18万，2018.1-2019.12，中方合作者。
3.脊痛宁片物质基础与作用机理研究，天士力医药集团股份有限公司，90万，2017.1-2018.12.
4.从中药及天然药物中寻找作用于核孤儿受体Nur77小分子调节剂，国家自然科学青年科学基金（NSFC：81001373），2011,1-2013,12，20.0万元。
近五年发表的代表性文章：
1.Xinran Geng#, Yichang Ren#, Fangfang Wang, Danmei Tian, Xinsheng Yao, Youwei Zhang*, Jinshan Tang*. Harmines inhibit cancer cell growth through coordinated activation of apoptosis and inhibition of autophagy. Biochem Bioph Res Co., 2018, 498 (1): 99-104.
2.Xiao-san Li, Yi-chang Ren, Yu-zhou Bao, Jie Liu, Xiao-kun Zhang, You-wei Zhang, Xue-Long Sun, Xin-sheng Yao*, Jin-Shan Tang*. Synthesis of C3-Neoglycosides ofDigoxigeninand Their Anticancer Activities.Eur. J. Med. Chem.,2018, 145: 252-262.
3.Jinshan Tang, Evgeny Ozhegov, Yang Liu, Dan Wang, Xinsheng Yao, Xuelong Sun*. Straightforward synthesis of N-glycan polymers from free glycans via cyanoxyl free radical-mediated polymerization.ACS Macro Lett. 2017, 6: 107-111.
4.Dongdong Wang, Xiaosan Li, Yuzhou Bao, Jie Liu, Xiaokun Zhang, Xinsheng Yao, Xuelong Sun,Jinshan Tang*. Synthesis of MeON-Neoglycosides of digitoxigenin with 6-deoxy- and 2,6-dideoxy-d-glucose derivatives and their anticancer activity.Bioorg. Med. Chem. Lett. 2017, 27: 3359-3364.
5.Jingjing Zhu#, Xinxin Zhang#,*, Yunqiu Miao, Shufang He, Danmei Tian, Xinsheng Yao,Jinshan Tang*, Yong Gan*. Delivery of acetylthevetin B, an antitumor cardiac glycoside, using polymeric micelles for enhanced therapeutic efficacy against lung cancer cells.Acta Pharmacologica Sinica, 2017, 38: 290-300.
6.Chang-Zhi Lai#, Hai-Bin Liu#, Jian-Xin Liu, Qin Ouyang, Shu-Wen Pang, Hua Zhou, Hai-Yan Tian, Liang Liu, Xin-Sheng Yao*,Jin-Shan Tang*.Hirundigenin type C21steroidal glycosides fromCynanchum stauntoniiand their anti-inflammatory activity.RSC Advances, 2016, 6, 59257-59268.
7.Dan-Mei Tian, Huo-Yun Cheng, Miao-Miao Jiang, Wei-Zai Shen,Jin-Shan Tang*, Xin-Sheng Yao*. Cardiac glycosides from the seeds of Thevetia peruviana.J. Nat. Prod., 2016, 79, 38-50.
8.Ru-Jian Yu#, Hai-Bin Liu#, Yang Yu, Lu Liang, Rui Xu,Jin-Shan Tang*, Chun Liang*, Xin-Sheng Yao*. Anticancer activities of proanthocyanidins from the plantUrceola huaitingii and their synergistic effects in combination with chemotherapeutics.Fitoterapia2016, 112, 175-182.
9.Jie-Feng Tian#, Peng-Ju Li#, Xiao-Xia Li, Ping-Hua Sun, Hao Gao, Xing-Zhong Liu, Peng Huang,Jin-Shan Tang*, Xin-Sheng Yao*. New antibacterial isocoumarin glycosides from a wetland soil derived fungal strainMetarhizium anisopliae.Bioorg. Med. Chem. Lett. 2016, 26 (5): 1391-1396.
10.Jie-Feng Tian, Ru-Jian Yu, Xiao-Xia Li, Hao Gao, Liang-Dong Guo, Yan Li, Jia Li, Jin-Shan Tang*, Xin-Sheng Yao*. Galiellalactone analogs and their possible precursors fromSarcosomataceae.Fitoterapia2015, 101: 92-98.
11.Yanping, Chen, Qian Liu, Hao Gao*, Hai-Peng Lin, Hai-Yan Tian, Kui Hong, Jia Li, RenWang Jiang, Xin-Sheng Yao and Jin-Shan Tang*. Streptospirodienoic acids A and B, 6,6-spiroketal polyketides from Streptomycessp. RSC Adv., 2014, 4: 63324–63327.
12.Xiaosan Li, Meng-Jie Hu, Jie Liu, Qian Liu, Zhi-Xing Huang, Shun-Lin Li, Xiao-Jiang Hao, Xiao-Kun Zhang, Xin-Sheng Yao,Jin-Shan Tang*. Cardiac glycosides from the bark of Antiaris toxicaria.Fitoterapia.2014, 97: 71-77.
13.Qian Liu#, Jinshan Tang#, Mengjie Hu, Jie Liu, Haifeng Chen, Hao Gao, Guanghui Wang, Shunlin Li, Xiaojiang Hao, Xiaokun Zhang, and Xinsheng Yao. Cardiac glycosides from the latex of Antiaris toxicaria (Pers.) LESCH and their inhibitory effects on the proliferation of cancer cell line.J. Nat. Prod., 2013, 76: 1771-1780.
主要社会兼职：
《天然产物研究与开发》青年编委2016-2018
联系方式：020-85220785
Email：gztangjinshan@126.com
