Education

• Ph.D. in Neurobiology (2004-2008)  ,University of Catholic Louvain,Belgium

  Thesis advisor: Prof. Andre M. Goffinet

• M. S. in Embryology & Human Anatomy (2000-2003), Sun Yat-Sen University, Guangzhou, China

  Thesis advisor: Prof. Zhibin Yao and Prof. Yiwen Ruan

• B. S. in Clinic Medicine (1992-1997), Yunyang Medical College

Research Experience

Professor and Principal Investigator (Nov2012-present ):

GHM Institute of CNS Regeneration, Jinan University

Research Interests: Spinal cord injury and Repair; Molecular mechanisms of axonal growth; Neural plasticity.

Professor and Principal Investigator (Jul2009-Oct2012):

Joint Laboratory of Brain Function and Health, Jinan University & The University of Hongkong, Medical School of Jinan University

Research Interests: Spinal cord injury and Repair; Molecular mechanisms of axonal growth; Neural plasticity.

Research Associate (Aug2008-Jun2009):

Center for Neuroscience, University of Catholic Louvain, Belgium

Mentor: Prof. Andre M. Goffinet

Research Interests: Molecular mechanisms of axonal growth.

Teaching Experience

Professor in Human Anatomy (Aug2009-present ):

Medical School of Jinan University

Undergraduate students in Clinic Medicine, BioMedicine, Biological Engineering, Pharmocology.

Professor in Neurobiology (Aug2009-present ):

GHM Institute of CNS Regeneration

Postgraduate students in Neurobiology, Advanced Neurobiology, Frontier in Neuroscience.

Teaching Assistant and Lecturer in Human Anatomy (Sept1997- Jan2004):

Yunyang Medical College

Undergraduate students in Clinic Medicine

Honors and awards

1. New Century Excellent Talents, 2009, Ministry of Education of the People’s Republic of China.

2. Candidate for “hundred and thousand of talents” program. 2010; Guangdong Province.

3. Young Talents of JNU; 2013; Jinan University

4. The Leading talent of special program for Hundred, Thousand and Ten Thousand of Guangdong province, China; 2014

Grant support

1. National Key R&D Program of China: Therapeutic Roles of Stem Cell–Derived Small Extracellular Vesicles in Hepatic and Neural Regeneration—Advances in Scalable Manufacturing and Translational Development. Project No. 2022YFA1104900; Dec 2022–Nov 2027; ¥830,000; Principal Investigator: Zhou Libing.

2. Major National Science and Technology Projects: Therapeutic Efficacy of Protein-Based Drug Nanocapsules in a Cynomolgus Monkey Model of Traumatic Craniocerebral Injury. Project No. XJZ2023010001; Jun 2024–May 2027; ¥2,400,000; Principal Investigator: Zhou Libing.

3. National Natural Science Foundation of China: Mechanistic Investigation of Celsr2-Mediated Regulation of Astrocyte Morphology and Function in Spinal Cord Injury Repair. Project No. 82271400; Jan 2023–Dec 2026; ¥530,000; Principal Investigator: Zhou Libing.

4. Guangzhou Key Projects of Brain Science and Brain-Like Intelligence Technology: Clinical Translation of Stem Cell–Derived Exosomes Combined with Intelligent Rehabilitation for Spinal Cord Injury Treatment. Project No. 20220600003; Apr 2022–Mar 2025; ¥1,500,000; Principal Investigator: Zhou Libing.

5. Guangzhou Key Projects of Brain Science and Brain-Like Intelligence Technology: Non-humane primate models of spinal cord injury and optic nerve injury. Project No. 20200730009; Aug 2020–Sept 2024; ¥10,000,000; Principal Investigator: Zhou Libing.

6. National Natural Science Foundation of China: Effect and Potential Mechanisms of Celsr2 Inhibition in Spinal Motoneurons for Promoting Axonal Regeneration and Functional Recovery Following Spinal Root Avulsion Injury. Project No. 81971148; Jan 2020–Dec 2023; ¥550,000; Principal Investigator: Zhou Libing.

7. Guangdong Provincial Key Project in Brain Science and Brain-Inspired Intelligence: Key Technologies for the Treatment of Neuropsychiatric Disorders—Stem Cell–Derived Exosomes in Spinal Cord Injury Therapy. Project  No. 2018B030332001; Jan 2019–Dec 2021; ¥4,560,000; Principal Investigator: Zhou Libing.

8. Guangzhou Major Special Project for Health and Medical Collaborative Innovation: Preclinical and Clinical Translational Research on Neural Stem Cell–Mediated Repair of Central Nervous System Functional Impairment. Project No. 201803040016-2; Apr 2018–Mar 2021; ¥920,000; Principal Investigator: Zhou Libing.

9. National Natural Science Foundation of China: International Cooperation and Exchange Program — Functional Roles of Auts2 in Cerebral Cortical Development and Cross-Species Evolutionary Divergence. Project No. 31811530148; Jan 2018–Dec 2019; ¥100,000; Principal Investigator: Zhou Libing.

10. National Natural Science Foundation of China: Mechanistic Roles of CELSR3 and FZD3 in Cellular Mediation of Human Embryonic Forebrain Neural Circuit Assembly. Project No. 31771133; Jan 2018–Dec 2021; ¥630,000; Principal Investigator: Zhou Libing.

11. Key project of Natural Science Foundation of Guangdong province: Cell Type–Specific Conditional Knockout of Frizzled3 and Celsr3 in the Retina: Impacts on Cellular Development, Circuit Assembly, and Visual Function. Project No. 1614050000335; ¥300,000; 2016-209; Principal Investigator: Zhou Libing.

12. National Key Basic Research Program of China (973 Program): Central Structural Plasticity and Functional Recovery Following Peripheral Nerve Injury. Project No. 2014CB542205; 2015–2019; ¥2,470,000; Principal Investigator: Zhou Libing.

13. National Natural Science Foundation of China: Exercise Intervention–Induced Remodeling of the Spinal Cord Microenvironment and Neural Circuit Plasticity in Mice with Corticospinal Tract Absent. Project No. 81571186; 2016–2019; ¥684,000; Principal Investigator: Zhou Libing.

14. Science & Technology Planning and Key Technology Innovation Projects of Guangdong: The Role of Exercise and Stem Cells in Spinal Cord Injury Repair. Project No. 2014B050504006; 2015–2017; ¥2,000,000; Principal Investigator: Zhou Libing.

15. Health and Medical Collaborative Innovation Major Projects of Guangzhou: Research on Key Technologies for Obtaining Functional Neural Stem Cells and Their Therapeutic Effects on the Nervous System. Project No. 201400000003-2; 2014–2017; ¥1,350,000; Principal Investigator: Zhou Libing.

16. Guangdong University International and Hong Kong, Macao and Taiwan Science and Technology Cooperation Innovation Platform: Central Nervous System Regeneration and Repair. Project No. 2013gjhz0002; 2014–2016; ¥500,000; Principal Investigator: Zhou Libing.

17. National Natural Science Foundation of China: The effect and mechanism of conditional Celsr3 knockout in the retina on the development of mouse retina. Project No. 31371101; Jan 2014–Dec 2014; ¥150,000; Principal Investigator: Zhou Libing.

18. National Key Basic Research Program of China (973 Program): Axon Regeneration and Myelin Repair. Project No. 2011CB504402; 2011–2015; ¥1,560,000; Principal Investigator: Zhou Libing.

19. National Natural Science Foundation of China: Compensation of Motor-related Neural Structures and Its Cellular and Molecular Mechanisms in Celsr3|Emx1 Mice. Project No. 81171152; 2012–2015; ¥570,000; Principal Investigator: Zhou Libing.

20. National Natural Science Foundation of China: Mechanistic Investigation of Cellular and Celsr3-Dependent Guidance of Neuronal Axon Growth. Project No. 31070955; 2011–2013; ¥330,000; Principal Investigator: Zhou Libing.

21. New Century Excellent Talents Support Program-Ministry of Education of the People’s Republic of China: Research on Central Nervous System Plasticity. Project No. NCET-10-0109; 2010–2013; ¥500,000; Principal Investigator: Zhou Libing.

Publications

1. Li W#, Hu R#, Mao J#, Wo J#, Zhang Y, Chen L, Liu Y, Li Z, Lin Y, Du M*, Chen Y*, Zhou* L, Guo T*. Quantum Photothermal Self-Monitoring Fiber Probes for In Vivo Photothermal Therapy. Adv Sci (Weinh). 2026 May 20:e75733. doi: 10.1002/advs.75733. Epub ahead of print. PMID: 42159412.

2. Zhang Y#, Sun F#, Wo J#, Yu L, Weng H, Huang Z, Li W, Jia B, He M, Li A*, Zhou L*. Piezo2 inhibition enhances the survival and axonal regeneration of spinal motoneurons after brachial plexus avulsion. Neural Regen Res. 2026 Apr 14. doi: 10.4103/NRR.NRR-D-25-00991. Epub ahead of print. PMID: 41975617.

3. Li F#, Huang Z#, Zhou J#, Wu Z, Deng XH, Weng H, Peng W, Li J, So KF, Fu QL*, Zhou L*. Small extracellular vesicles loaded with neurotrophin-3 confer multitargeted therapeutic effects in treating spinal cord injury. Nano Research, 2026, https://doi.org/10.26599/NR.2026.94908424.

4. Song X, Li C, Yang Y, Huang C, Chen M, Lin S, Huang Z, Wang W, Liao K, Wei H, Wang L, Xu H, Chen Y, Lin Y, Li J, Dai Z, Xie W, Zheng X, Wu J, Gao J, Wu J, Tu Z, Zhou L, Huang L, Ren C, So KF, Yin P, Yang H, Li S, Lai L, Li XJ, Yan S. Alleviation of mutant TDP-43-mediated neuropathology by inducible stem cells in monkeys. Int J Biol Sci. 2026 Jan 1;22(1):25-42. doi: 10.7150/ijbs.122557. PMID: 41362729; PMCID: PMC12681693.

5. Liu A#, Geng X#, Li X, Xi Y, Han Q, Wang X, Shen Y*, Zhou L*. Atypical cadherin CELSR2 acts as a therapeutic target for glioma through WNT3A/β-catenin signaling. Cell Death Dis. 2025 Nov 3;16(1):786. doi: 10.1038/s41419-025-08116-8. PMID: 41184253; PMCID: PMC12583761.

6. Liang X, Song C, Lin J, Li S, Li L, Dai G, Zhang R, Zou OM, Yao H, Zhou L, Zou Y. Transthyretin, a novel prognostic marker of POCD revealed by time-series RNA-sequencing analysis. Mol Psychiatry. 2025 Jul;30(7):3103-3119. doi: 10.1038/s41380-025-02918-0. Epub 2025 Feb 15. PMID: 39955470.

7. Huang Z#, Li J#, Wo J#, Li CL, Wu ZC, Deng XH, Liang Y, Li F, Chen B, Jia B, Wang L, Wang Y, Sun G, Li Z, Zhu H, Guest JD, So KF*, Fu QL*, Zhou L.* Intranasal Delivery of Brain-Derived Neurotrophic Factor (BDNF)-Loaded Small Extracellular Vesicles for Treating Acute Spinal Cord Injury in Rats and Monkeys. J Extracell Vesicles. 2025 Apr;14(4):e70066. doi: 10.1002/jev2.70066. PMID: 40194993; PMCID: PMC11975507.

8. Zhu H, Guest JD, Dunlop S, Xie JX, Gao S, Luo Z, Springer JE, Wu W, Young W, Poon WS, Liu S, Gao H, Yu T, Wang D, Zhou L, Wu S, Zhong L, Niu F, Wang X, Liu Y, So KF, Xu XM. Surgical intervention combined with weight-bearing walking training promotes recovery in patients with chronic spinal cord injury: a randomized controlled study. Neural Regen Res. 2024 Dec 1;19(12):2773-2784. doi: 10.4103/NRR.NRR-D-23-01198. Epub 2024 Jan 31. PMID: 38595294; PMCID: PMC11168509.

9. Lai W, Zhao Y, Chen Y, Dai Z, Chen R, Niu Y, Chen X, Chen S, Huang G, Shan Z, Zheng J, Hu Y, Chen Q, Gong S, Kang S, Guo H, Ma X, Song Y, Xia K, Wang J, Zhou L, So KF, Wang K, Qiu S, Zhang L, Chen J, Shi L. Autism patient-derived SHANK2BY29X mutation affects the development of ALDH1A1 negative dopamine neuron. Mol Psychiatry. 2024 Oct;29(10):3180-3194. doi: 10.1038/s41380-024-02578-6. Epub 2024 May 4. PMID: 38704506; PMCID: PMC11449796.

10. Zhou J#, Li F#, Jia B#, Wu Z, Huang Z, He M, Weng H, So KF, Qu W, Fu QL*, Zhou L.* Intranasal delivery of small extracellular vesicles reduces the progress of amyotrophic lateral sclerosis and the overactivation of complement-coagulation cascade and NF-ĸB signaling in SOD1G93A mice. J Nanobiotechnology. 2024 Aug 22;22(1):503. doi: 10.1186/s12951-024-02764-2. PMID: 39174972; PMCID: PMC11340036.

11. Weng H#, Deng L#, Wang T#, Xu H, Wu J, Zhou Q, Yu L, Chen B, Huang L, Qu Y, Zhou L*, Chen X*. Humid heat environment causes anxiety-like disorder via impairing gut microbiota and bile acid metabolism in mice. Nat Commun. 2024 Jul 7;15(1):5697. doi: 10.1038/s41467-024-49972-w. PMID: 38972900; PMCID: PMC11228019.

12. Song C, Li S, Mai Y, Li L, Dai G, Zhou Y, Liang X, Zou OM, Wang Y, Zhou L*, Liu J*, Zou Y*. Dysregulated expression of miR-140 and miR-122 compromised microglial chemotaxis and led to reduced restriction of AD pathology. J Neuroinflammation. 2024 Jul 2;21(1):167. doi: 10.1186/s12974-024-03162-z. PMID: 38956605; PMCID: PMC11218311.

13. Chen B, Wang L, Li X, Shi Z, Duan J, Wei JA, Li C, Pang C, Wang D, Zhang K, Chen H, Na W, Zhang L, So KF, Zhou L, Jiang B, Yuan TF, Qu Y. Celsr2 regulates NMDA receptors and dendritic homeostasis in dorsal CA1 to enable social memory. Mol Psychiatry. 2024 Jun;29(6):1583-1594. doi: 10.1038/s41380-022-01664-x. Epub 2022 Jul 4. PMID: 35789199.

14. Li M, Xu J, Zou Y, Lu J, Ou A, Ma X, Zhang J, Xu Y, Fu L, Liu J, Wang X, Zhou L, Guo J. Motor neuron-specific RhoA knockout delays degeneration and promotes regeneration of dendrites in spinal ventral horn after brachial plexus injury. Neural Regen Res. 2023 Dec;18(12):2757-2761. doi: 10.4103/1673-5374.373657. PMID: 37449641; PMCID: PMC10358699.

15. Ruan Y, Cheng J, Dai J, Ma Z, Luo S, Yan R, Wang L, Zhou J, Yu B, Tong X, Shen H, Zhou L*, Yuan TF*, Han Q*. Chronic stress hinders sensory axon regeneration via impairing mitochondrial cristae and OXPHOS. Sci Adv. 2023 Oct 6;9(40):eadh0183. doi: 10.1126/sciadv.adh0183. Epub 2023 Oct 6. PMID: 37801508; PMCID: PMC10558127.

16. Liu A, Yu L, Li X, Zhang K, Zhang W, So KF, Tissir F, Qu Y*, Zhou L*. Celsr2-mediated morphological polarization and functional phenotype of reactive astrocytes in neural repair. Glia. 2023 Aug;71(8):1985-2004. doi: 10.1002/glia.24378. Epub 2023 Apr 26. PMID: 37186402.

17. Chen M, Chen Z, Xiao X, Zhou L, Fu R, Jiang X, Pang M, Xia J. Corticospinal circuit neuroplasticity may involve silent synapses: Implications for functional recovery facilitated by neuromodulation after spinal cord injury. IBRO Neurosci Rep. 2022 Aug 18;14:185-194. doi: 10.1016/j.ibneur.2022.08.005. PMID: 36824667; PMCID: PMC9941655.

18. Zhou X, Deng X, Liu M, He M, Long W, Xu Z, Zhang K, Liu T, So KF, Fu QL*, Zhou L*. Intranasal delivery of BDNF-loaded small extracellular vesicles for cerebral ischemia therapy. J Control Release. 2023 May;357:1-19. doi: 10.1016/j.jconrel.2023.03.033. Epub 2023 Mar 28. PMID: 36958402.

19. Yu L, Liu M, Li F, Wang Q, Wang M, So KF, Qu Y, Zhou L*. Celsr2 Knockout Alleviates Inhibitory Synaptic Stripping and Benefits Motoneuron Survival and Axon Regeneration After Branchial Plexus Avulsion. Mol Neurobiol. 2023 Apr;60(4):1884-1900. doi: 10.1007/s12035-022-03198-3. Epub 2023 Jan 3. PMID: 36593433; PMCID: PMC9984348.

20. Su X#, Yang S#, Li Y, Xiang Z, Tao Q, Liu S, Yin Z*, Zhong L*, Lv X*, Zhou L*. γδ T cells recruitment and local proliferation in brain parenchyma benefit anti-neuroinflammation after cerebral microbleeds. Front Immunol. 2023 Mar 29;14:1139601. doi: 10.3389/fimmu.2023.1139601. PMID: 37063908; PMCID: PMC10090560.

21. Li C, Wei JA, Wang D, Luo Z, Pang C, Chen K, Duan J, Chen B, Zhou L, Tissir F, Shi L, So KF, Zhang L, Qu Y. Planar cell polarity protein Celsr2 maintains structural and functional integrity of adult cortical synapses. Prog Neurobiol. 2022 Dec;219:102352. doi: 10.1016/j.pneurobio.2022.102352. Epub 2022 Sep 8. PMID: 36089108.

22. Liu Y, Wo J, Zhu H, Huang Z, Zhou P, Yang J, Zheng S, Zhou L, Tan F, Sun G, Li Z. Cervical subtotal discectomy prosthesis validated in non-human primate model: A novel artificial cervical disc replacement concept? Front Bioeng Biotechnol. 2022 Oct 13;10:997877. doi: 10.3389/fbioe.2022.997877. PMID: 36312530; PMCID: PMC9606661.

23. Chen B, Li F, Jia B, So KF, Wei JA, Liu Y, Qu Y, Zhou L*. Celsr3 Inactivation in the Brainstem Impairs Rubrospinal Tract Development and Mouse Behaviors in Motor Coordination and Mechanic-Induced Response. Mol Neurobiol. 2022 Aug;59(8):5179-5192. doi: 10.1007/s12035-022-02910-7. Epub 2022 Jun 9. PMID: 35678978; PMCID: PMC9363480.

24. Wen Q#, Weng H#, Liu T, Yu L, Zhao T, Qin J, Li S, Wu Q, Tissir F, Qu Y*, Zhou L*. Inactivating Celsr2 promotes motor axon fasciculation and regeneration in mouse and human. Brain. 2022 Apr 18;145(2):670-683. doi: 10.1093/brain/awab317. PMID: 34983065; PMCID: PMC9014747.

25. Lian WY, Lu ZP, Zhao W, Zou JQ, Lu ZY, Zhou LB, Lei HY. The Role of Klotho Protein Against Sevoflurane-Induced Neuronal Injury. Neurochem Res. 2022 Feb;47(2):315-326. doi: 10.1007/s11064-021-03444-5. Epub 2021 Sep 8. PMID: 34498160.

26. Hakanen J, Parmentier N, Sommacal L, Garcia-Sanchez D, Aittaleb M, Vertommen D, Zhou L, Ruiz-Reig N, Tissir F. The Celsr3-Kif2a axis directs neuronal migration in the postnatal brain. Prog Neurobiol. 2022 Jan;208:102177. doi: 10.1016/j.pneurobio.2021.102177. Epub 2021 Sep 25. PMID: 34582949.

27. Wang Q, Li D, Cao G, Shi Q, Zhu J, Zhang M, Cheng H, Wen Q, Xu H, Zhu L, Zhang H, Perry RJ, Spadaro O, Yang Y, He S, Chen Y, Wang B, Li G, Liu Z, Yang C, Wu X, Zhou L, Zhou Q, Ju Z, Lu H, Xin Y, Yang X, Wang C, Liu Y, Shulman GI, Dixit VD, Lu L, Yang H, Flavell RA, Yin Z. IL-27 signalling promotes adipocyte thermogenesis and energy expenditure. Nature. 2021 Dec;600(7888):314-318. doi: 10.1038/s41586-021-04127-5. Epub 2021 Nov 24. PMID: 34819664.

28. Huang ZH, Feng AY, Liu J, Zhou L, Zhou B, Yu P. Inhibitor of DNA binding 2 accelerates nerve regeneration after sciatic nerve injury in mice. Neural Regen Res. 2021 Dec;16(12):2542-2548. doi: 10.4103/1673-5374.313054. PMID: 33907046; PMCID: PMC8374553.

29. Zhou Q, Qin J, Liang Y, Zhang W, He S, Tissir F, Qu Y, Zhou L*. Celsr3 is required for Purkinje cell maturation and regulates cerebellar postsynaptic plasticity. iScience. 2021 Jul 1;24(7):102812. doi: 10.1016/j.isci.2021.102812. PMID: 34308297; PMCID: PMC8283331.

30. Xiao Q, Guo T, Li J, Li L, Chen K, Zhou L, Wu W, So KF, Ramakrishna S, Liu B, Rong L, Chen G, Xing X, He L. Macrophage polarization induced by sustained release of 7,8-DHF from aligned PLLA fibers potentially for neural stem cell neurogenesis. Mater Sci Eng C Mater Biol Appl. 2021 Jan;118:111415. doi: 10.1016/j.msec.2020.111415. Epub 2020 Aug 24. PMID: 33255017.

31. Zhao T, Chen Y, Sun Z, Shi Z, Qin J, Lu J, Li C, Ma D, Zhou L, Song X. Prenatal sevoflurane exposure causes neuronal excitatory/inhibitory imbalance in the prefrontal cortex and neurofunctional abnormality in rats. Neurobiol Dis. 2020 Dec;146:105121. doi: 10.1016/j.nbd.2020.105121. Epub 2020 Sep 29. PMID: 33007389.

32. Chen ST, Lai WJ, Zhang WJ, Chen QP, Zhou LB, So KF, Shi LL. Insulin-like growth factor 1 partially rescues early developmental defects caused by SHANK2 knockdown in human neurons. Neural Regen Res. 2020 Dec;15(12):2335-2343. doi: 10.4103/1673-5374.285002. PMID: 32594058; PMCID: PMC7749486.

33. Liu AM, Chen BL, Yu LT, Liu T, Shi LL, Yu PP, Qu YB, So KF, Zhou LB*. Human adipose tissue- and umbilical cord-derived stem cells: which is a better alternative to treat spinal cord injury? Neural Regen Res. 2020 Dec;15(12):2306-2317. doi: 10.4103/1673-5374.284997. PMID: 32594054; PMCID: PMC7749492.

34. Liu A, Kang S, Yu P, Shi L*, Zhou L*. Transplantation of human urine-derived neural progenitor cells after spinal cord injury in rats. Neurosci Lett. 2020 Sep 14;735:135201. doi: 10.1016/j.neulet.2020.135201. Epub 2020 Jun 23. PMID: 32585253.

35. Liu H, Xu X, Tu Y, Chen K, Song L, Zhai J, Chen S, Rong L, Zhou L, Wu W, So KF, Ramakrishna S, He L. Engineering Microenvironment for Endogenous Neural Regeneration after Spinal Cord Injury by Reassembling Extracellular Matrix. ACS Appl Mater Interfaces. 2020 Apr 15;12(15):17207-17219. doi: 10.1021/acsami.9b19638. Epub 2020 Apr 2. PMID: 32207300.

36. Qin J, Wang M, Zhao T, Xiao X, Li X, Yang J, Yi L, Goffinet AM, Qu Y*, Zhou L*. Early Forebrain Neurons and Scaffold Fibers in Human Embryos. Cereb Cortex. 2020 Mar 14;30(3):913-928. doi: 10.1093/cercor/bhz136. PMID: 31298263.

37. Huang Z, Liu J, Jin J, Chen Q, Shields LBE, Zhang YP, Shields CB, Zhou L, Zhou B, Yu P. Inhibitor of DNA binding 2 promotes axonal growth through upregulation of Neurogenin2. Exp Neurol. 2019 Oct;320:112966. doi: 10.1016/j.expneurol.2019.112966. Epub 2019 May 28. PMID: 31145898.

38. Zhang H, Sun G, Li X, Fu Z, Guo C, Cao G, Wang B, Wang Q, Yang S, Li D, Xia X, Li P, Zhu J, Zhou W, Zheng L, Li J, Zhang L, Hao J, Zhou L, Bornancin F, Li Z, Yin Z, Gao Y. Inhibition of MALT1 paracaspase activity improves lesion recovery following spinal cord injury. Sci Bull (Beijing). 2019 Aug 30;64(16):1179-1194. doi: 10.1016/j.scib.2019.04.026. Epub 2019 Apr 22. PMID: 36659689.

39. Sun G, Yang S, Cai H, Shu Y, Han Q, Wang B, Li Z, Zhou L, Gao Q, Yin Z. Molybdenum disulfide nanoflowers mediated anti-inflammation macrophage modulation for spinal cord injury treatment. J Colloid Interface Sci. 2019 Aug 1;549:50-62. doi: 10.1016/j.jcis.2019.04.047. Epub 2019 Apr 16. PMID: 31015056.

40. Chen S, Hou Y, Zhao Z, Luo Y, Lv S, Wang Q, Li J, He L, Zhou L, Wu W. Neuregulin-1 Accelerates Functional Motor Recovery by Improving Motoneuron Survival After Brachial Plexus Root Avulsion in Mice. Neuroscience. 2019 Apr 15;404:510-518. doi: 10.1016/j.neuroscience.2019.01.054. Epub 2019 Feb 5. PMID: 30731156.

41. Zhang W, Yang B, Weng H, Liu T, Shi L, Yu P, So KF, Qu Y, Zhou L. Wheel Running Improves Motor Function and Spinal Cord Plasticity in Mice With Genetic Absence of the Corticospinal Tract. Front Cell Neurosci. 2019 Mar 19;13:106. doi: 10.3389/fncel.2019.00106. PMID: 30941019; PMCID: PMC6433830.

42. Zhou Q, Xiang H, Li A, Lin W, Huang Z, Guo J, Wang P, Chi Y, Xiang K, Xu Y, Zhou L, So KF, Chen X, Sun X, Ren Y. Activating Adiponectin Signaling with Exogenous AdipoRon Reduces Myelin Lipid Accumulation and Suppresses Macrophage Recruitment after Spinal Cord Injury. J Neurotrauma. 2019 Mar 19;36(6):903-918. doi: 10.1089/neu.2018.5783. Epub 2018 Oct 30. PMID: 30221582.

43. Huang G, Chen S, Chen X, Zheng J, Xu Z, Doostparast Torshizi A, Gong S, Chen Q, Ma X, Yu J, Zhou L, Qiu S, Wang K, Shi L. Uncovering the Functional Link Between SHANK3 Deletions and Deficiency in Neurodevelopment Using iPSC-Derived Human Neurons. Front Neuroanat. 2019 Mar 13;13:23. doi: 10.3389/fnana.2019.00023. PMID: 30918484; PMCID: PMC6424902.

44. Yu P, Zhang W, Liu Y, Sheng C, So KF, Zhou L*, Zhu H*. The effects and potential mechanisms of locomotor training on improvements of functional recovery after spinal cord injury. Int Rev Neurobiol. 2019;147:199-217. doi: 10.1016/bs.irn.2019.08.003. Epub 2019 Sep 16. PMID: 31607355.

45. Sun G, Yang S, Cao G, Wang Q, Hao J, Wen Q, Li Z, So KF, Liu Z, Zhou S, Zhao Y, Yang H, Zhou L*, Yin Z*. γδ T cells provide the early source of IFN-γ to aggravate lesions in spinal cord injury. J Exp Med. 2018 Feb 5;215(2):521-535. doi: 10.1084/jem.20170686. Epub 2017 Dec 27. PMID: 29282251; PMCID: PMC5789408.

46. Jin J, Tilve S, Huang Z, Zhou L, Geller HM, Yu P. Effect of chondroitin sulfate proteoglycans on neuronal cell adhesion, spreading and neurite growth in culture. Neural Regen Res. 2018 Feb;13(2):289-297. doi: 10.4103/1673-5374.226398. PMID: 29557379; PMCID: PMC5879901.

47. Li J, Chen S, Zhao Z, Luo Y, Hou Y, Li H, He L, Zhou L, Wu W. Effect of VEGF on Inflammatory Regulation, Neural Survival, and Functional Improvement in Rats following a Complete Spinal Cord Transection. Front Cell Neurosci. 2017 Nov 29;11:381. doi: 10.3389/fncel.2017.00381. PMID: 29238292; PMCID: PMC5712574.

48. Kang S, Chen X, Gong S, Yu P, Yau S, Su Z, Zhou L, Yu J, Pan G, Shi L. Characteristic analyses of a neural differentiation model from iPSC-derived neuron according to morphology, physiology, and global gene expression pattern. Sci Rep. 2017 Sep 25;7(1):12233. doi: 10.1038/s41598-017-12452-x. PMID: 28947763; PMCID: PMC5612987.

49. Wang F, Wang Q, Li C, Yu P, Qu Y, Zhou L*. The role of Celsr3 in the development of central somatosensory projections from dorsal root ganglia. Neuroscience. 2017 Sep 17;359:267-276. doi: 10.1016/j.neuroscience.2017.07.040. Epub 2017 Jul 25. PMID: 28754314.

50. Lin K, Xu G, Shi L, Lu W, Guan L, Ouyang H, Chen K, Dang Y, Zhou L, So KF. CACNA1C polymorphisms Impact Cognitive Recovery in Patients with Bipolar Disorder in a Six-week Open-label Trial. Sci Rep. 2017 Aug 1;7(1):7022. doi: 10.1038/s41598-017-07368-5. PMID: 28765577; PMCID: PMC5539285.

51. Sun X, Jones ZB, Chen XM, Zhou L, So KF, Ren Y. Multiple organ dysfunction and systemic inflammation after spinal cord injury: a complex relationship. J Neuroinflammation. 2016 Oct 6;13(1):260. doi: 10.1186/s12974-016-0736-y. PMID: 27716334; PMCID: PMC5053065.

52. Feng J, Xian Q, Guan T, Hu J, Wang M, Huang Y, So KF, Evans SM, Chai G, Goffinet AM, Qu Y*, Zhou L*. Celsr3 and Fzd3 Organize a Pioneer Neuron Scaffold to Steer Growing Thalamocortical Axons. Cereb Cortex. 2016 Jul;26(7):3323-34. doi: 10.1093/cercor/bhw132. Epub 2016 May 11. PMID: 27170656; PMCID: PMC4898681.

53. Zhang N, Luo Y, He L, Zhou L, Wu W. A self-assembly peptide nanofibrous scaffold reduces inflammatory response and promotes functional recovery in a mouse model of intracerebral hemorrhage. Nanomedicine. 2016 Jul;12(5):1205-17. doi: 10.1016/j.nano.2015.12.387. Epub 2016 Jan 7. PMID: 26772423.

54. Zhao T, Li C, Wei W, Zhang H, Ma D, Song X*, Zhou L*. Prenatal ketamine exposure causes abnormal development of prefrontal cortex in rat. Sci Rep. 2016 May 26;6:26865. doi: 10.1038/srep26865. PMID: 27226073; PMCID: PMC4881038.

55. Shen N, Qu Y, Yu Y, So KF, Goffinet AM, Vardi N, Xu Y*, Zhou L*. Frizzled3 Shapes the Development of Retinal Rod Bipolar Cells. Invest Ophthalmol Vis Sci. 2016 May 1;57(6):2788-96. doi: 10.1167/iovs.16-19281. PMID: 27214687.

56. Han Q#, Cao C#, Ding Y#, So KF, Wu W, Qu Y*, Zhou L*. Plasticity of motor network and function in the absence of corticospinal projection. Exp Neurol. 2015 May;267:194-208. doi: 10.1016/j.expneurol.2015.03.008. Epub 2015 Mar 17. PMID: 25792481.

57. Chai G, Zhou L, Manto M, Helmbacher F, Clotman F, Goffinet AM, Tissir F. Celsr3 is required in motor neurons to steer their axons in the hindlimb. Nat Neurosci. 2014 Sep;17(9):1171-9. doi: 10.1038/nn.3784. Epub 2014 Aug 10. PMID: 25108913.

58. Zhao T, Li Y, Wei W, Savage S, Zhou L*, Ma D*. Ketamine administered to pregnant rats in the second trimester causes long-lasting behavioral disorders in offspring. Neurobiol Dis. 2014 Aug;68:145-55. doi: 10.1016/j.nbd.2014.02.009. Epub 2014 Apr 26. PMID: 24780497.

59. Qu Y, Huang Y, Feng J, Alvarez-Bolado G, Grove EA, Yang Y, Tissir F, Zhou L*, Goffinet AM*. Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):E2996-3004. doi: 10.1073/pnas.1402105111. Epub 2014 Jul 7. PMID: 25002511; PMCID: PMC4115502.

60. Ding Y, Qu Y, Feng J, Wang M, Han Q, So KF, Wu W*, Zhou L*. Functional motor recovery from motoneuron axotomy is compromised in mice with defective corticospinal projections. PLoS One. 2014 Jul 8;9(7):e101918. doi: 10.1371/journal.pone.0101918. PMID: 25003601; PMCID: PMC4087004.

61. Zhang Z, Lai D, Wang L, Yu P, Zhu L, Guo B, Xu L, Zhou L, Sun Y, Lee SM, Wang Y. Neuroprotective effects of the andrographolide analogue AL-1 in the MPP⁺/MPTP-induced Parkinson's disease model in vitro and in mice. Pharmacol Biochem Behav. 2014 Jul;122:191-202. doi: 10.1016/j.pbb.2014.03.028. Epub 2014 Apr 12. PMID: 24726706.

62. Chen J, Zhou L, Pan SY. A brief review of recent advances in stem cell biology. Neural Regen Res. 2014 Apr 1;9(7):684-7. doi: 10.4103/1673-5374.131565. PMID: 25206872; PMCID: PMC4146274.

63. Feng G, Zhang Z, Bao Q, Zhang Z, Zhou L, Jiang J, Li S. Protective effect of chinonin in MPTP-induced C57BL/6 mouse model of Parkinson's disease. Biol Pharm Bull. 2014;37(8):1301-7. doi: 10.1248/bpb.b14-00128. Epub 2014 May 28. PMID: 24871044.

64. Feng J, Xu Y, Wang M, Ruan Y, So KF, Tissir F, Goffinet A, Zhou L*. A role for atypical cadherin Celsr3 in hippocampal maturation and connectivity. J Neurosci. 2012 Oct 3;32(40):13729-43. doi: 10.1523/JNEUROSCI.1965-12.2012. PMID: 23035085; PMCID: PMC6704772.

65. Feng J, Han Q, Zhou L*. Planar cell polarity genes, Celsr1-3, in neural development. Neurosci Bull. 2012 Jun;28(3):309-15. doi: 10.1007/s12264-012-1232-8. PMID: 22622831; PMCID: PMC5560321.

66. Qu Y, Glasco DM, Zhou L, Sawant A, Ravni A, Fritzsch B, Damrau C, Murdoch JN, Evans S, Pfaff SL, Formstone C, Goffinet AM, Chandrasekhar A, Tissir F. Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice. J Neurosci. 2010 Jul 14;30(28):9392-401. doi: 10.1523/JNEUROSCI.0124-10.2010. PMID: 20631168; PMCID: PMC3069688.

67. Zhou L, Gall D, Qu Y, Prigogine C, Cheron G, Tissir F, Schiffmann SN, Goffinet AM. Maturation of "neocortex isole" in vivo in mice. J Neurosci. 2010 Jun 9;30(23):7928-39. doi: 10.1523/JNEUROSCI.6005-09.2010. PMID: 20534841; PMCID: PMC6632698.

68. Tissir F, Qu Y, Montcouquiol M, Zhou L, Komatsu K, Shi D, Fujimori T, Labeau J, Tyteca D, Courtoy P, Poumay Y, Uemura T, Goffinet AM. Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus. Nat Neurosci. 2010 Jun;13(6):700-7. doi: 10.1038/nn.2555. Epub 2010 May 16. PMID: 20473291.

69. Chen LJ, Zhang FG, Li J, Song HX, Zhou LB, Yao BC, Li F, Li WC. Expression of calcitonin gene-related peptide in anterior and posterior horns of the spinal cord after brachial plexus injury. J Clin Neurosci. 2010 Jan;17(1):87-91. doi: 10.1016/j.jocn.2009.03.042. Epub 2009 Dec 6. PMID: 19969463.

70. Zhou L, Qu Y, Tissir F, Goffinet AM. Role of the atypical cadherin Celsr3 during development of the internal capsule. Cereb Cortex. 2009 Jul;19 Suppl 1:i114-9. doi: 10.1093/cercor/bhp032. Epub 2009 Apr 6. PMID: 19349379.

71. Zhou L, Goffinet AM, Tissir F. Rôle de la cadhérine Celsr3 dans la connectivité du cortex cérébral [Role of the cadherin Celsr3 in the connectivity of the cerebral cortex]. Med Sci (Paris). 2008 Dec;24(12):1025-7. French. doi: 10.1051/medsci/200824121025. PMID: 19116108.

72. Zhou L, Bar I, Achouri Y, Campbell K, De Backer O, Hebert JM, Jones K, Kessaris N, de Rouvroit CL, O'Leary D, Richardson WD, Goffinet AM, Tissir F. Early forebrain wiring: genetic dissection using conditional Celsr3 mutant mice. Science. 2008 May 16;320(5878):946-9. doi: 10.1126/science.1155244. PMID: 18487195; PMCID: PMC2746700.

73. Zhou L, Tissir F, Goffinet AM. The atypical cadherin Celsr3 regulates the development of the axonal blueprint. Novartis Found Symp. 2007;288:130-4; discussion 134-40, 276-81. doi: 10.1002/9780470994030.ch10. PMID: 18494256.

74. Zhou L, Jossin Y, Goffinet AM. Identification of small molecules that interfere with radial neuronal migration and early cortical plate development. Cereb Cortex. 2007 Jan;17(1):211-20. doi: 10.1093/cercor/bhj139. Epub 2006 Feb 15. PMID: 16481563.

75. Price DJ, Kennedy H, Dehay C, Zhou L, Mercier M, Jossin Y, Goffinet AM, Tissir F, Blakey D, Molnár Z. The development of cortical connections. Eur J Neurosci. 2006 Feb;23(4):910-20. doi: 10.1111/j.1460-9568.2006.04620.x. PMID: 16519656.

Patent portfolio

1. Chinese Invention Patent. Zhou Libing; Wo Jin; Liu Xiaowen; Li Jing; Huang Zhonghai; Sun Guodong; Li Zhizhong. Data Acquisition Device and Method for Non-Human Primate Behavioral Studies. ZL 2021 1 1105987.X. Authorized: April 15, 2025.

2. Chinese Utility Model Patent. Zhou Libing; Liu Xiaowen; Li Jing; Wo Jin; Huang Zhonghai; Sun Guodong; Li Zhizhong. Vest-Based System for Behavioral Data Acquisition in Macaques. ZL 2021 2 2298736.X. Authorized: April 19, 2022.

3. Chinese Utility Model Patent. Zhou Libing; Li Jing; Liu Xiaowen; Wo Jin; Huang Zhonghai; Sun Guodong; Li Zhizhong. Hoist-Mounted Platform for Non-Invasive Behavioral Monitoring in Non-Human Primates. ZL 2021 2 2295227.1. Authorized: April 19, 2022.

4. Chinese Utility Model Patent. Zhou Libing; Li Jing; Liu Xiaowen; Wo Jin; Huang Zhonghai; Sun Guodong; Li Zhizhong. Modular Frame Assembly for Integrated Behavioral Data Collection in Macaques. ZL 2021 2 2298739.3. Authorized: April 19, 2022.

5. Chinese Utility Model Patent. Zhou Libing; Liu Xiaowen; Huang Zhonghai; Li Jing; Wo Jin; Sun Guodong; Li Zhizhong. Treadmill System for Gait and Locomotor Assessment in Non-Human Primates. ZL 2021 2 2323249.4. Authorized: April 19, 2022.

6. Chinese Utility Model Patent. Zhou Libing; Liu Xiaowen; Li Jing; Wo Jin; Huang Zhonghai; Sun Guodong; Li Zhizhong. Adjustable Restraint Garment for Standardized Behavioral Testing in Non-Human Primates. ZL 2021 2 2295226.7. Authorized: May 10, 2022.

7. Chinese Utility Model Patent. Zhou Libing; Wo Jin; Luo Jing; Liu Xiaowen; Li Jing; Huang Zhonghai; Sun Guodong; Li Zhizhong. Stereotactic Fixation Device for Transcranial Stimulation–Evoked Motor Potential Recording. ZL 2021 2 2295230.3. Authorized: July 12, 2022.

8. Chinese Invention Patent. Sun Guodong; Liu Xiaowen; Wo Jin; Zhou Libing; Li Zhizhong. Interactive Behavioral Training Inducer for Non-Human Primates: Composition, Preparation Method, and Therapeutic Application. CN202111159006.X. Filed: September 30, 2021.

9. Chinese Utility Model Patent. Zhou Libing; Li Jing; Huang Zhonghai; Chen Boli; Wo Jin; Wang Meizhi. Integrated System for Quantitative Motor Behavior Assessment in Non-Human Primates. ZL 2022 2 1185017.5. Authorized: November 29, 2022.

10. Chinese Utility Model Patent. Zhou Libing; Huang Zhonghai; Li Jing; Wo Jin; Liang Yayin; Liu Mengfan; Jia Bin; Li Zhizhong; Sun Guodong. Nasal Delivery Device for Targeted Neurotherapeutics in Non-Human Primates. ZL 2022 2 2992681.7. Authorized: August 22, 2023.

11. Chinese Utility Model Patent. Li Jing; Zhou Libing; Huang Zhonghai; Wang Meizhi; Lin Yu. Apparatus for Quantitative Lower-Limb Muscle Strength Evaluation in Non-Human Primates. ZL 2024 2 2344749.X. Authorized: September 30, 2025.

12. Chinese Utility Model Patent. Zhou Libing; Li Jing; Huang Zhonghai; Wang Meizhi; Lin Yu. Dual-Function Cognitive Assessment Platform for Non-Human Primates. ZL 2024 2 2385663.1. Authorized: July 11, 2025.

13. Chinese Invention Patent. Zhou Libing; Li Jing; Huang Zhonghai; Wang Meizhi; Lin Yu. Dual-Function Cognitive Assessment Platform for Non-Human Primates: Composition, Fabrication, and Validation Protocol. 202411372106.4. Filed: September 29, 2024.

14. Chinese Invention Patent. Liu Aimei; Zhou Libing. CELSR2 as a Theranostic Target in Glioma: Use of CELSR2 Modulation in Diagnostic Imaging and Targeted Therapy. 202411001264.9. Filed: November 8, 2024.

15. Chinese Invention Patent. Fu Qingling; Zhou Libing. NT3-Enriched Small Extracellular Vesicles: Production Method, Characterization, and Applications in Neural Repair and Functional Recovery. 2025107175819. Filed: May 29, 2025.

Supervising students

PhD Students: Jia FENG (2010-2014); Yuetong DING (2011-2014); Qi HAN (2012-2015); Ning SHEN (2013-2016); Bin YANG (2014-present); Wei ZHNAG (2015-2018); Aimei LIU (2016-2020); Qinji ZHOU (2017-2021); Huandi WENG (2019-2022); Zhonghai HUANG (2019-2022); Boli CHEN (2020-2024); Lintai YU (2021-2024); Yu LIN (2021-2024)；Fengwei Sun (2022-2025); Yunsong ZHANG (2023-2026); Bin JIA (2024-present); Song WANG (2024-present); Wenhui LONG (2025-present)

Master Students：Qi HAN (2010-2012); Biao LIN (2011-2014); Liting HUANG (2012-2015); Tainyun ZHAO (2012-2015); Qianghua WANG (2013-2016); Feifei WANG (2013-2016); Quanxiang XIAN (2014-2017); Jinwen QIN (2015-2018); Xue XIAO (2015-2018); Tao LIU (2016-2019); Huandi WENG (2016-2019); Boli CHEN (2017-2020); Lintai YU (2018-2021); Yaying LIANG (2019-2021); Fuxiang LI (2020-2023); Mengfan LIU (2020-2023); Bin JIA  (2021-2024)；Meiting HE(2022-2025)；Wenhui LONG (2022-2025); Kun HU (2023-2026); Kexin SHI (2023-2026); Jiajun CAI (2024-present); Xinjiu OU (2024-present); Zi GUO (2025-present); Tianxiang XIE (2025-present)

Postdocs: Quan WEN (2017-2019); Jing LI (2017-2019); Shuxian YANG (2020-2022); Xin ZHOU (2020-2022.12); Jin WO (2021-2023)；Huandi WENG (2022-2024);Haoran ZHU (2023-2025); Zhonghai HUANG (2022-present); Feiwei SUN (2026-present).