Compulsory Courses

Medicinal Chemistry
Author: Date:27-11-2007 Hits:

 

Objectives:
 
The student will develop an understanding of mechanisms of drug action at the molecular level and gain insights as to how physiochemical properties of drugs affect their principal therapeutic applications and/or toxicity, stability, absorption, distribution, metabolism, and excretion. The students are required to understand the medicinal chemistry of the main classes of drugs covered by this course.
 
Requirements:
 
1.  Structure-activity relationships: In this course, we will provide the student with an understanding and appreciation of the influence chemical structures have on drug action (i.e., structure-activity relationships);
2.  Molecular features of drugs: To familiarize the student with molecular features of drugs relating to (a) their stability in terms of shelf life and (b) their compatibility in terms of physiochemical and therapeutic characteristics;
3.  Mechanisms of Drug Action: To render the student aware of mechanisms of drug action at the molecular level and to provide insights as to how physiochemical properties of drugs affect their activity and/or toxicity, absorption, distribution, metabolism, and excretion;
4.  Design and Development of Drug Entities: To illustrate to the student the significance of chemical structure, physiochemical properties, and molecular modification in the rational design and development of drug entities;
5.  Drug Nomenclature: To apprise the student of drug nomenclature, including generic, proprietary, and chemical designations;
6.  Therapeutic Applications: To relate drug chemistry to the principal therapeutic applications of medicinal agents;
7.  Chemically Synthesis: To familiarize the synthesis routes of some key drugs.
 
Contents:
 
This course is divided into two parts: theory study and experiment. According to the new training project, the experiment of medicinal chemistry is designed as independent course which the basic skill of drug synthesis will be trained, the detail can be seen in the Laboratory Syllabus for experimental medicinal chemistry.
 
The theory study part is structured with lecture and case study.
 
Lecture will be given using PPT, and the all contents can be seen on internet course: http://course.jnu.edu.cn/cxgc/ywhx/ywhx/Index.htm. The typical drugs will be lectured in every lesson. For the key drugs study, the teaching method is that their chemical structures are selected as starting point, then introducing their discovery, synthesis, physio-chemical properties, their activity and/or toxicity, absorption, distribution, metabolism, and excretion, etc. Lecture will be given in lively language, explaining the profound things in a simple way, finding their rules to make student easy study, easy remember.
 
In the part of case study, the drug usage cases selected from the literature both home and aboard will be studied and discussed in the class. Through the case discussion, make students link together the theory of medicinal chemistry with the drug usage, understand and realize the how the pharmacists serve the society with their knowledge. This part make students not only study lively, and also make them feel the work practice of pharmacists, and train students synthetically.
 
In order to suit with the nature of our university, The students from mainland and non-mainland will be divided into two classes. One class of the mainland students will pay attention to the drug design and chemical synthesis since their training target as the talents of innovation drug research; the another class of non-mainland will pay attention to the physico-chemical properties and drug usages as the target to the talents of drug application.
 
There are a lot of English reading and study materials about the medicinal chemistry in this class.
 
Credits: 4



Last:Pharmacology

Next:Microbiology and Immunology